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Ginkgetin: Advances on Resources, Bioactivity, and Pharmacology

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Handbook of Dietary Flavonoids

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Abstract

Ginkgetin is the first known biflavonoid, isolated from the leaves of Ginkgo biloba L. after which it was named. It is a derivative of amentoflavone with two methoxy groups (7,4′-dimethylamentoflavone). Besides the ginkgo leaves, its presence has been confirmed in more than 20 other plant species, most of which are known in traditional medicine. For more than 30 years, it has been the focus of scientific attention as a possible effective anticancer agent and as an agent with beneficial effects on neurological diseases. This chapter summarizes the current data on the anticancer and neuroprotective effects of ginkgetin. In addition, information was provided on the potential anti-inflammatory, antiviral, antibacterial, antifungal, and antiparasitic effects of ginkgetin, as well as its potential role in cardiovascular health. At the end of the chapter, also its toxicology and safety are also discussed.

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References

  • Adnan M, Rasul A, Hussain G, Shah MA, Zahoor MK, Anwar H, Sarfraz I, Riaz A, Manzoor M, Adem S, Selamoglu Z (2020) Ginkgetin: a natural biflavone with versatile pharmacological activities. Food Chem Toxicol 145:111642

    Article  CAS  PubMed  Google Scholar 

  • Attallah NGM, Al-Fakhrany OM, Elekhnawy E, Hussein IA, Shaldam MA, Altwaijry N, Alqahtani MJ, Negm WA (2022) Anti-biofilm and antibacterial activities of Cycas media R. Br secondary metabolites: in silico, in vitro, and in vivo approaches. Antibiotics 11:993

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Baek SH, Lee JH, Ko J-H, Lee H, Nam D, Lee SG, Yang WM, Um J-Y, Lee J, Kim S-H, Shim BS, Ahn KS (2016) Ginkgetin blocks constitutive STAT3 activation and induces apoptosis through induction of SHP-1 and PTEN tyrosine phosphatases. Phytother Res 30(4):567–576

    Article  CAS  PubMed  Google Scholar 

  • Barbalho SM, Direito R, Laurindo LF, Marton LT, Guiguer EL, Goulart RdA, Tofano RJ, Carvalho ACA, Flato UAP, Capelluppi Tofano VA, et al (2022) Ginkgo biloba in the Aging Process: A Narrative Review. Antioxidants 11(3):525. https://doi.org/10.3390/antiox11030525

  • Bhadresha K, Upadhyay V, Kumar SP, Pandya P, Jain N, Rawal RM (2021) Computational investigation of ginkgetin and theaflavin as potential inhibitors of heat shock protein 90 (Hsp90). J Biomol Struct Dyn 40:1–7

    Google Scholar 

  • Çankaya İİT, Devkota HP, Zengin G, Šamec D (2023) Neuroprotective potential of biflavone ginkgetin: a review. Life 13(2):562

    Article  Google Scholar 

  • Cao Y, Tan N-H, Chen J-J, Zeng G-Z, Ma Y-B, Wu Y-P, Yan H, Yang J, Lu L-F, Wang Q (2010) Bioactive flavones and biflavones from Selaginella moellendorffii Hieron. Fitoterapia 81(4):253–258

    Article  CAS  PubMed  Google Scholar 

  • Cao J, Tong C, Liu Y, Wang J, Ni X, Xiong M (2017) Ginkgetin inhibits growth of breast carcinoma via regulating MAPKs pathway. Biomed Pharmacother 96:450–458

    Article  CAS  PubMed  Google Scholar 

  • Castañeda P, Garcia M-R, Hernandez B-E, Torres B-A, Anaya A-L, Mata R (1992) Effects of some compounds isolated from Celaenodendron mexicanum Standl. (Euphorbiaceae) on seeds and phytopathogenic fungi. J Chem Ecol 18(7):1025–1037

    Article  PubMed  Google Scholar 

  • Chandran G, Muralidhara (2014) Insights on the neuromodulatory propensity of Selaginella (Sanjeevani) and its potential pharmacological applications. CNS Neurol Disord Drug Targets 12:82–95

    Google Scholar 

  • Chen T-R, Wei L-H, Guan X-Q, Huang C, Liu Z-Y, Wang F-J, Hou J, Jin Q, Liu Y-F, Wen P-H, Zhang S-J, Ge G-B, Guo W-Z (2019) Biflavones from Ginkgo biloba as inhibitors of human thrombin. Bioorg Chem 92:103199

    Article  CAS  PubMed  Google Scholar 

  • Cho YL, Park JG, Jin KH, Kim W, Ji CM, Jang JH, Know MG, Kim S, Lee SH, Lee J, Kim YG, Park YJ, Kim WK, Bae KH, Kwon BM, Chung SJ, Min JK (2019) Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation. Pharmacol Res 139:325–336

    Article  CAS  PubMed  Google Scholar 

  • Choi S-K, Oh H-M, Lee S-K, Jeong D-G, Ryu S-E, Son K-H, Han D-C, Sung N-D, Baek N-I, Kwon B-M (2006) Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3). Nat Prod Res 20(4):341–346

    Article  CAS  PubMed  Google Scholar 

  • Das B, Padma Rao S, Srinivas KVNS, Yadav JS (1995) Lignans, biflavones and taxoids from Himalayan Taxus baccata. Phytochemistry 38(3):715–717

    Google Scholar 

  • Dey D, Hossain R, Biswas P, Paul P, Islam MA, Ema TI, Galn BK, Hasan MM, Blbl S, Islam MT, Rahman MA, Klm B (2022) Amentoflavone derivatives significantly act towards the main protease (3CLPRO/MPRO) of SARS-CoV-2: in silico admet profiling, molecular docking, molecular dynamics simulation, network pharmacology. Mol Divers 27:857–871

    Article  PubMed  PubMed Central  Google Scholar 

  • Ghosh R, Chakraborty A, Biswas A, Chowdhuri S (2020) Computer aided identification of potential SARS CoV-2 main protease inhibitors from diterpenoids and biflavonoids of Torreya nucifera leaves. J Biomol Struct Dyn 40:2647–2662

    Article  PubMed  Google Scholar 

  • Hanrahan JR, Chebib M, Davucheron NLM, Hall BJ, Johnston GAR (2003) Semisynthetic preparation of amentoflavone: a negative modulator at GABAA receptors. Bioorg Med Chem Lett 13(14):2281–2284

    Article  CAS  PubMed  Google Scholar 

  • Hao DC, Hou XD, Gu XJ, Xiao PG, Ge GB (2021) Ethnopharmacology, chemodiversity, and bioactivity of Cephalotaxus medicinal plants. Chin J Nat Med 19:321–338

    CAS  PubMed  Google Scholar 

  • Haruyama T, Nagata K (2013) Anti-influenza virus activity of Ginkgo biloba leaf extracts. J Nat Med 67:636–642

    Article  CAS  PubMed  Google Scholar 

  • Hayashi K, Hayashi T, Morita N (1992) Mechanism of action of the antiherpesvirus biflavone ginkgetin. Antimicrob Agents Chemother 36(9):1890–1893

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • He X, Yang F, Huang X (2021) Proceedings of chemistry, pharmacology, pharmacokinetics and synthesis of biflavonoids. Molecules 26:6088

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hu WH, Chan GKL, Duan R, Wang HY, Kong XP, Dong TTX, Tsim KWK (2019) Synergy of ginkgetin and resveratrol in suppressing VEGF-induced angiogenesis: a therapy in treating colorectal cancer. Cancers 11:1828

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hyun SK, Kang SS, Son KH, Chung HY, Choi JS (2005) Biflavone glucosides from Ginkgo biloba yellow leaves. Chem Pharm Bull 53:1200–1201

    Article  CAS  Google Scholar 

  • Jeon YJ, Jung SN, Yun J, Lee CW, Choi J, Lee YJ, Han DC, Kwon BM (2015) Ginkgetin inhibits the growth of DU−145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity. Cancer Sci 106:413–420

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jeong E-J, Hwang L, Lee M, Lee K-Y, Ahn M-J, Sung S-H (2013) Neuroprotective biflavonoids of Chamaecyparis obtusta leaves against glutamate-induced oxidative stress in HT22 hippocampal cells. Food ant Chemical Toxicology 64:397–402

    Article  Google Scholar 

  • Katsila T, Spyroulias GA, Patrinos GP, Matsoukas MT (2016) Computational approaches in target identification and drug discovery. Comput Struct Biotechnol J 14:177–184

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kaur P, Chaudhary A, Singh B, Gopichand (2011) Simultaneous quantification of flavonoids and biflavonoids in Ginkgo biloba using RP-HPTLC densitometry method. J Planar Chromatogr Mod TLC 24:507–512

    Article  CAS  Google Scholar 

  • Khan M-S, Kumar I, Prasad J-S, Nagarajan G-R, Parthasarathy M-R, Krishnamurty H-G (1976) Phenolic constituents of Taxus baccaca leaves. Planta Med 30(1):82–85

    Article  CAS  PubMed  Google Scholar 

  • Kim HK, Son KH, Chang HW, Kang SS, Kim HP (1999) Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from Ginkgo biloba leaves. Planta Med 65:465–467

    Article  CAS  PubMed  Google Scholar 

  • Koirala N, Thuan NH, Ghimire GP, Thang DV, Sohng JK (2016) Methylation of flavonoids: chemical structures, bioactivities, progress and perspectives for biotechnological production. Enzym Microb Technol 86:103–116

    Article  CAS  Google Scholar 

  • Konda Y, Sasaki T, Kagawa H, Takayanagi H, Harigaya Y (1995) Conformational analysis of C3’-C8 connected biflavones. J Heterocyclic Chem 32(25):1531–1535

    Article  CAS  Google Scholar 

  • Kovač Tomas M, Jurčević I, Šamec D (2023) Tissue-specific profiling of biflavonoids in ginkgo (Ginkgo biloba L.). Plants 12(1):147

    Article  Google Scholar 

  • Krauze-Baranowska M, Wiwart M (2003) Antifungal activity of biflavones from Taxus baccata and Ginkgo biloba. Z Naturforsch C 58:65–69

    Article  CAS  PubMed  Google Scholar 

  • Krauze-Baranowska M, Pobłocka L, El Hela A-A (2005) Biflavones from Chamaecyparis obtusa. Z Naturforsch C 60(9–10):679–685

    Article  CAS  PubMed  Google Scholar 

  • Krauze-Baranowska M (2004) Flavonoids from Metasequoia glyptostroboides. Acta Pol Pharm 61(3):199–202

    CAS  PubMed  Google Scholar 

  • Lee M-K, Lim S-W, Yang H, Sung S-H, Lee H-S, Park M-J, Kim Y-C (2006) Osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana. Bioorg Med Chem Lett 16(11):2850–2854

    Article  CAS  PubMed  Google Scholar 

  • Lee Y-J, Kang Y-R, Lee SY, Jin Y, Han DC, Kwon B-M (2017) Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation of b-Myb and miRNA34a expression. Int J Oncol 51(4):1331–1342

    Article  CAS  PubMed  Google Scholar 

  • Li W, Deng Y, Dai R, Yu Y, Saeed M-K, Li L, Meng W, Zhang X (2007) Chromatographic fingerprint analysis of Cephalotaxus sinensis from various sources by high-performance liquid chromatography-diodearray detectiion-electronspray ionization-tandem mass spectrometry. J Pharm Biomed Anal 45(1):38–46

    Article  CAS  PubMed  Google Scholar 

  • Li J, Li F, Lu Y-Y, Su X-J, Huang C-P, Lu X-W (2010) A new dilactone from the seeds of Gaultheria yunnanensis. Fitoterapia 81(1):35–37

    Article  CAS  PubMed  Google Scholar 

  • Li D, Liu JP, Han X, Wang YF, Wang CH, Li Z, Wang GC (2017) Chemical constituents of the whole plants of Houttuynia cordata. Chem Nat Compd 53:365–367

    Article  CAS  Google Scholar 

  • Li G, Wang G, Wang S, Deng Y (2019a) Ginkgetin in vitro and in vivo reduces Streptococcus suis virulence by inhibiting suilysin activity. J Appl Microbiol 127:1556–1563

    Article  CAS  PubMed  Google Scholar 

  • Li M, Li B, Xia ZM, Tian Y, Zhang D, Rui WJ, Dong JX, Xiao FJ (2019b) Anticancer effects of five biflavonoids from Ginkgo biloba L. male flowers in vitro. Molecules 24:1496

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li Q, Ye T, Long T, Peng X (2019c) Ginkgetin exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Biosci Biotechnol Biochem 83:675–683

    Article  CAS  PubMed  Google Scholar 

  • Li Y-Y, Lu X-Y, Sun J-L, Wang Q-Q, Zhang Y-D, Zhang J-B, Fan X-H (2019d) Potential hepatic and renal toxicity induced by the biflavonoids from Ginkgo biloba. Chin J Nat Med 17(9):672–681

    CAS  PubMed  Google Scholar 

  • Lian N, Tong J, Li W, Wu J, Li Y (2018) Ginkgetin ameliorates experimental atherosclerosis in rats. Biomed Pharmacother 102:510–516

    Article  CAS  PubMed  Google Scholar 

  • Lim H, Son KH, Chang HW, Kang SS, Kim HP (2006) Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation. Biol Pharm Bull 29:1046–1049

    Article  CAS  PubMed  Google Scholar 

  • Liu X-Q, Zhang X-D, Zhu Y-L, Shin B-Y, Wu S-X (2008) Structure identification of biflavones and determination of Taxol from Taxus media. Zhong Yao Cai 31(10):1498–1501

    CAS  PubMed  Google Scholar 

  • Liu P-K, Weng Z-M, Ge G-B, Li H-L, Ding L-L, Dai Z-R, Hou X-D, Leng Y-H, Yu Y, Hou J (2018) Biflavones from Ginkgo biloba as novel pancreatic lipase inhibitors: inhibition potentials and mechanism. Int J Biol Macromol 118(B):2216–2223

    Article  CAS  PubMed  Google Scholar 

  • Liu L, Geng X, Zhang J, Li S, Gao J (2022) Structure-based discovery of Licoflavone B and Ginkgetin targeting c-Myc G-quadruplex to suppress c-Myc transcription and myeloma growth. Chem Biol Drug Des 100:525–533

    Article  CAS  PubMed  Google Scholar 

  • Lou J-S, Bi W-C, Chan GKL, Jin Y, Wong C-W, Zhou Z-Y, Wang H-Y, Yao P, Dong TTX, Tsim KWK (2017) Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget 8(54):93131–93148

    Article  PubMed  PubMed Central  Google Scholar 

  • Lou JS, Zhao LP, Huang ZH, Chen XY, Xu JT, Chi-Shing W, Tsim KWK, Chen YT, Xie T (2021) Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer. Phytomedicine 80:153370

    Article  CAS  PubMed  Google Scholar 

  • Mei N, Guo X, Ren Z, Kobayashi D, Wada K, Guo L (2017) Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports. J Environ Sci Health C 35:1–28

    Article  CAS  Google Scholar 

  • Mendiratta A, Dayal R, Bartley J-P, Smith G (2017) A phenylpropanoid and biflavonoids from the needles of Cephalotaxus hrarringtonia var. harringtonia. Nat Prod Commun 12(11):1777–1778

    Google Scholar 

  • Meng A-P, Li J, Pu S-B (2018) Chemical constituents of leaves of Taxus chinensis. Chem Nat Compd 54(5):841–845

    Article  CAS  Google Scholar 

  • Miki K, Nagai T, Suzuki K, Tsujimura R, Koyama K, Kinoshita K, Furuhata K, Yamada H, Takahashi K (2007) Anti-influenza virus activity of biflavonoids. Bioorg Med Chem Lett 17:772–775

    Article  CAS  PubMed  Google Scholar 

  • Nabati F, Moradi M, Mohabatkar H (2020) In silico analyzing the molecular interactions of plant-derived inhibitors against E6AP, p53, and c-Myc binding sites of HPV type 16 E6 oncoprotein. Mol Biol Res Commun 9:71–82

    CAS  PubMed  PubMed Central  Google Scholar 

  • Nakazawa K, Ito M (1962) Synthesis of ginkgetin. Tetrahedron Lett 3(8):317–319

    Article  Google Scholar 

  • Pan L-L, Wu W-J, Zheng G-F, Han X-Y, He J-S, Cai Z (2017) Corrigendum to: Ginkgetin inhibits proliferation of human leukemia cells via the TNF-α signaling pathway. Z Naturforsch C 72(11–12):507–507

    Article  CAS  PubMed  Google Scholar 

  • Pan J, Li X, Guo F, Yang Z, Zhang L, Yang C (2019) Ginkgetin attenuates cerebral ischemia–reperfusion induced autophagy and cell death via modulation of the NF-κB/p53 signaling pathway. Biosci Rep 39:BSR20191452

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pandey R, Chandra P, Arya KR, Kuma B (2014) Development and validation of an ultra high performance liquid chromatography electrospray ionization tandem mass spectrometry method for the simultaneous determination of selected flavonoids in Ginkgo biloba. J Sep Sci 37:3610–3618

    Article  CAS  PubMed  Google Scholar 

  • Pang H-L, Zhu G-H, Zhou Q-H, Ai C-Z, Zhu Y-D, Wang P, Dou T-Y, Xia Y-L, Ma H, Ge G-B (2022) Discovery and characterization of the key constituents in Ginkgo biloba leaf extract with potent inhibitory effects on human UDP-glucuronosyltransferase 1A1. Front Pharmacol 13:1663–9812

    Article  Google Scholar 

  • Parveen N, Taufeeq H-M, Khan N-U-D (1985) Biflavones from the leaves of Himalayan yew: Taxus wallichiana. J Nat Prod 48(6):994–994

    Article  CAS  Google Scholar 

  • Pattamadilok D, Suttisri R (2008) Seco-terpenoids and their constituents from Elateriospermum tapos. J Nat Prod 71(2):292–294

    Article  CAS  PubMed  Google Scholar 

  • Rahaman SO, Alharbi MO, Dutta B, Goswami R (2020) Identification and functional characterization of a biflavone as a novel inhibitor of TRPV4-dependent proatherogenic processes in macrophages. FASEB J 34:1

    Google Scholar 

  • Rana S, Kumar P, Sharma A, Sharma S, Giri R, Ghosh KS (2021) Identification of naturally occurring antiviral molecules for SARS-CoV-2 mitigation. Open COVID J 1:38–46

    Article  Google Scholar 

  • Ren G, Xu G, Li R, Xie H, Cui Z, Wang L (2022) Modulation of bleomycin-induced oxidative stress and pulmonary fibrosis by ginkgetin in mice via AMPK. Curr Mol Pharmacol 15:10

    Google Scholar 

  • Ruan X, Yan L-Y, Li X-X, Liu B, Zhang H, Wang Q (2014) Optimization of process parameters of extraction of amentoflavone, quercetin and ginkgetin from Taxus chinensis using supercritical CO2 plus CO-solvent. Molecules 19(11):17682–17696

    Article  PubMed  PubMed Central  Google Scholar 

  • Ryu YB, Jeong HJ, Kim JH, Kim YM, Park JY, Kim D, Nguyen TTH, Park SJ, Chang JS, Park KH, Rho MC, Lee WS (2010) Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition. Bioorg Med Chem 18:7940–7947

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Šamec D, Pierz V, Srividya N, Wüst M, Lange BM (2019) Assessing chemical diversity in Psilotum nudum (L.) Beauv., a pantropical whisk fern that has lost many of its fern-like characters. Front Plant Sci 10:868

    Article  PubMed  PubMed Central  Google Scholar 

  • Šamec D, Karalija E, Šola I, Vujčić BV, Salopek-Sondi B (2021) The role of polyphenols in abiotic stress response: the influence of molecular structure. Plan Theory 10:118

    Google Scholar 

  • Šamec D, Karalija E, Dahija S, Hassan STS (2022) Biflavonoids: important contributions to the health benefits of ginkgo (Ginkgo biloba L.). Plants 11:1381

    Article  PubMed  PubMed Central  Google Scholar 

  • Shen N, Liu Y, Cui Y, Xin H (2022) Large-scale targetedly isolation of biflavonoids with high purity from industrial waste Ginkgo biloba exocarp using two-dimensional chromatography coupled with macroporous adsorption resin enrichment. Ind Crop Prod 175:114264

    Article  CAS  Google Scholar 

  • Shi S, Zhou H, Zhang Y, Huang K (2008) Hyphenated HSCCC-DPPH for rapid preparative isolation and screening of antioxidants from Selaginella moellendorffii. Chromatographia 68:173–178

    Article  CAS  Google Scholar 

  • Song Y-Q, He R-J, Pu D, Guan X-Q, Shi J-H, Li Y-G, Hou J, Jia S-N, Qin W-W, Fang S-Q, Ge G-B (2021) Discovery and characterization of the biflavones from Ginkgo biloba as highly specific and potent inhibitors against human carboxylesterase 2. Front Pharmacol 12. https://doi.org/10.3389/fphar.2021.655659

  • Sun C-M, Syu W, Huang Y-T, Chen C-C, Ou J-C (1997) Selective cytotoxicity of ginkgetin from Selaginella moellendorffii. J Nat Prod 60:382–384

    Article  CAS  PubMed  Google Scholar 

  • Tao Z, Jin W, Ao M, Zhai S, Xu H, Yu L (2019) Evaluation of the anti-inflammatory properties of the active constituents in Ginkgo biloba for the treatment of pulmonary diseases. Food Funct 10:2209–2220

    Article  CAS  PubMed  Google Scholar 

  • Tao Y, Zhu F, Pan M, Liu Q, Wang P (2022) Pharmacokinetic, metabolism, and metabolomic strategies provide deep insight into the underlying mechanism of Ginkgo biloba flavonoids in the treatment of cardiovascular disease. Front Nutr 9. https://doi.org/10.3389/fnut.2022.857370

  • Tian Z, Tang C, Wang Z (2019) Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion via apoptosis inhibition and PI3K/Akt/mTOR signaling pathway activation. J Cell Biochem 120:18487–18495

    Article  CAS  PubMed  Google Scholar 

  • Wang YQ, Wang MY, Fu XR, Yu P, Gao GF, Fan YM, Duan XL, Zhao BL, Chang YZ, Shi ZH (2015a) Neuroprotective effects of ginkgetin against neuroinjury in Parkinson’s disease model induced by MPTP via chelating iron. Free Radic Res 49:1069–1080

    Article  CAS  PubMed  Google Scholar 

  • Wang G, Yao S, Zhang X-X, Song H (2015b) Rapid screening and structural characterization of antioxidants from the extract of Selaginella doederleinii Hieron with DPPH-UPLC-Q-TOF/MS method. Int J Anal Chem 2015:849769

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang LT, Fan XH, Jian Y, Dong MZ, Yang Q, Meng D, Fu YJ (2019) A sensitive and selective multiple reaction monitoring mass spectrometry method for simultaneous quantification of flavonol glycoside, terpene lactones, and biflavonoids in Ginkgo biloba leaves. J Pharm Biomed Anal 170:335–340

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Cheng R, Wu X, Miao M (2021) Neuroprotective and neurotrophic effects of ginkgetin and bilobalide on MPTP-induced mice with Parkinson’s disease. Pharmazie Int J Pharm Sci 76:27–33

    CAS  Google Scholar 

  • Wang B, Shi C, Feng L, Pan W, Tian X-G, Sun C-P, Wang C, Ning J, Lv X, Wang Y, Yuan Q-H, Guan R (2022) Potent inhibition of human cytochrome P450 3A4 by biflavone components from Ginkgo biloba and Selaginella tamariscina. Front Pharmacol 13. https://doi.org/10.3389/fphar.2022.856784

  • Wei L, Jian P, Erjiong H, Qihan Z (2021) Ginkgetin alleviates high glucose-evoked mesangial cell oxidative stress injury, inflammation and extracellular matrix (ECM) deposition in an AMPK/mTOR-mediated autophagy axis. Chem Biol Drug Des 98:620–630

    Article  CAS  PubMed  Google Scholar 

  • Weniger B, Vonthron-Sénécheau C, Kaiser M, Brun R, Anton R (2006) Comparative antiplasmodial, leishmanicidal and antitrypanosomal activities of several biflavonoids. Phytomedicine 13:176–180

    Article  CAS  PubMed  Google Scholar 

  • Xiong M, Wang L, Yu HL, Han H, Mao D, Chen J, Zeng Y, He N, Liu ZG, Wang ZY, Xu SJ, Guo LY, Wang YA (2015) Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9. Oncol Rep 15:1034–1040

    Google Scholar 

  • Xiong Y, Zhu GH, Wang HN, Hu Q, Chen LL, Guan XQ, Li HL, Chen HZ, Tang H, Ge GB (2021) Discovery of naturally occurring inhibitors against SARS-CoV-2 3CLpro from Ginkgo biloba leaves via large-scale screening. Fitoterapia 152:104909

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yamaguchi L-F, Kato M-J, Mascio P-D (2009) Biflavonoids from Araucaria angustifolia protect against DNA UV-induced damage. Phytochemistry 70(5):615–620

    Article  CAS  PubMed  Google Scholar 

  • Yang L, Zheng Z-S, Cheng F, Ruan X, Jiang D-A, Pan C-D, Wang Q (2016) Seasonal dynamics of metabolites in needles of Taxus wallichiana var. mairei. Molecules 21(10):1403

    Article  PubMed  PubMed Central  Google Scholar 

  • Ye Z-N, Yu M-Y, Kong L-M, Wang W-H, Yang Y-F, Liu J-Q, Qiu M-H, Li Y (2015) Biflavone ginkgetin, a novel Wnt inhibitor, suppresses the growth of medulloblastoma. Nat Prod Bioprospect 5(2):91–97

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • You OH, Kim S-H, Kim B, Sohn EJ, Lee H-J, Shim B-S, Yun M, Byung-Mog Kwon B-M, Kim S-H (2013) Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells. Bioorg Med Chem Lett 23(9):2692–2695

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Shi S, Wang Y, Huang K (2011) Target-guided isolation and purification of antioxidants from Selaginella sinensis by offline coupling DPPH-HPLC and HSCCC experiments. J Chromatogr B 879(2):191–196

    Article  CAS  Google Scholar 

  • Zhang J, Yang S, Chen F, Li H, Chen B (2017) Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway. Cell Biosci 7:44

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhang L, Liu J, Geng T (2019) Ginkgetin aglycone attenuates the apoptosis and inflammation response through nuclear factor-kB signaling pathway in ischemic-reperfusion injury. J Cell Biochem 120:8078–8085

    Article  CAS  PubMed  Google Scholar 

  • Zhao C, Ren X, Li C, Jiang H, Guan J, Su W, Li Y, Tian Y, Wang T, Li S (2019) Coupling ultrasound with heat-reflux to improve the extraction of quercetin, kaempferol, ginkgetin and sciadopitysin from Mairei yew leaves. Appl Sci 9:795

    Article  CAS  Google Scholar 

  • Zhou Z, Fu C (2013) A new flavanone and other constituents from the rhizomes of Cyperus rotundus and their antioxidant activities. Chem Nat Compd 48:963–965

    Article  CAS  Google Scholar 

  • Zhou H-F, Xie C, Jian R, Kang J, Li Y, Zhuang C-L, Yang F, Zhang L-L, Lai L, Wu T, Wu X (2011) Biflavonoids from carper (Capparis spinosa L.) fruits and their effects in inhibiting NF-kappa B activation. J Agric Food Chem 59(7):3060–3065

    Article  CAS  PubMed  Google Scholar 

  • Zhou G, Yao X, Tang Y, Yang N, Pang H, Mo X, Zhu S, Su S, Qian D, Jin C, Qin Y, Duan JA (2012) Two new nonacosanetriols from Ginkgo biloba sarcotesta. Chem Phys Lipids 165:731–736

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work has been supported by Croatian Science Foundation project “Biflavonoids role in plants: Ginkgo biloba L. as a model system” under the project no. UIP-2019-04-1018.

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Authors and Affiliations

  1. Department of Food Technology, University Center Koprivnica, University North, Koprivnica, Croatia

    Dunja Šamec

  2. Department of Food Technology, University Center Koprivnica, Koprivnica, Croatia

    Iva Jurčević-Šangut

  3. Department for Biology, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

    Erna Karalija

Authors
  1. Dunja Šamec
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  2. Iva Jurčević-Šangut
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  3. Erna Karalija
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Corresponding author

Correspondence to Dunja Šamec .

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Editors and Affiliations

  1. Department of Analytical Chemistry and Food Science, Universidade de Vigo, Vigo, Spain

    Jianbo Xiao

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Šamec, D., Jurčević-Šangut, I., Karalija, E. (2024). Ginkgetin: Advances on Resources, Bioactivity, and Pharmacology. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_64-2

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  • DOI: https://doi.org/10.1007/978-3-030-94753-8_64-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-94753-8

  • Online ISBN: 978-3-030-94753-8

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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  1. Latest

    Ginkgetin: Advances on Resources, Bioactivity, and Pharmacology
    Published:
    20 November 2023

    DOI: https://doi.org/10.1007/978-3-030-94753-8_64-2

  2. Original

    Ginkgetin: Advances on Resources, Bioactivity, and Pharmacology
    Published:
    19 September 2023

    DOI: https://doi.org/10.1007/978-3-030-94753-8_64-1

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