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Three new eremophilane sesquiterpenes and one new related derivative from Nemania sp. HDF-Br-5, an endophytic fungus of the endangered conifer Pseudotsuga gaussenii Flous
Phytochemistry Letters ( IF 1.7 ) Pub Date : 2022-03-02 , DOI: 10.1016/j.phytol.2022.02.011 Wenxin Ding 1 , Hao-Wei Chen 2 , Mengran Wang 1 , Miyang Wan 1 , Jin-Feng Hu 2 , Jiyang Li 1
更新日期：2022-03-02
Phytochemistry Letters ( IF 1.7 ) Pub Date : 2022-03-02 , DOI: 10.1016/j.phytol.2022.02.011 Wenxin Ding 1 , Hao-Wei Chen 2 , Mengran Wang 1 , Miyang Wan 1 , Jin-Feng Hu 2 , Jiyang Li 1
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Three new (psganpenes A-C), one known eremophilane sesquiterpene and one newrelated derivative (psganpene D) were isolated from the culture of endophytic fungus Nemania sp. HDF-Br-5, which derived from Pseudotsuga gaussenii Flous, anendangered conifer endemic to China. Their structures were deduced by extensive spectroscopic methods. All isolates were screened for cytotoxicity and antibacterial activity. Psganpene D showed promising cytotoxicity against KB, HCT116 and Hela cell strains, with IC50 values in the range of 15.1–32.3 μM.
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